MAST3 belongs to the microtubule-associated serine / threonine-protein kinase family, which is characterized by containing a serine/threonine kinase domain and a PDZ domain, and is highly expressed in brain (1). MSAT3 suppresses the degradation and promotes phosphorylation of tumor suppressor PTEN via binding to specific PDZ domains (2). MSAT3 is known to modulate the immune functions in inflammatory bowel diseases via regulating NF-kB, cell adhesion and/or migration and production of pro-inflammatory cytokines (3).
1. Garlanda, P. et al. Expression of the MAST family of serine/threonine kinases. Brain Research. (1195) 12-19, 2008.
2. Valiente, M. et al. Binding of PTEN to Specific PDZ Domains Contributes to PTEN Protein Stability and Phosphorylation by Microtubule-associated Serine/Threonine Kinases. The Journal of Biological Chemistry. (280) 28936–28943, 2005.
3. Labbé, C. et al. Genome-wide Expression Profiling Implicates a MAST3-Regulated Gene Set in Colonic Mucosal Inflammation of Ulcerative Colitis Patients. Inflamm Bowel Dis. (6) 1072–1080, 2012.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cell Cycle, Ser/Thr Kinases