Recombinant human LCK SH3 domain (58-124) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. L03-35G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
L03-35G-20 | 20 ug | $215 | |
L03-35G-50 | 50 ug | $435 | |
L03-35G-BULK | BULK | Contact Us |
Overview:
The LCK (Lymphocyte-Specific Protein Tyrosine Kinase) SH3 domain is a structural domain found in the LCK protein, a member of the Src family kinases. SFKs are critical regulators of signaling apthways involved in immune cell activation, including T-cell receptor (TCR) signaling. The SH3 domain in LCK, like other SH3 domains, play a key role in mediating protein-protein interactions, particularly with proline-rich motifs in target proteins. SH3 domains are modular protein domains with about 50-70 amino acids in length, known for their ability to bind to specific proline-rich motifs in other proteins. They are essential for the assembly of signaling complexes and are involved in diverse cellular processes, including cell signaling, cytoskeletal organization, and endocytosis. The SH3 domain of LCK likely facilitates interactions with downstream signaling molecules and adaptors, thereby participating in the regulation of TCR and immune responses.
Genbank Number:
References:
1. Thomas JW, et al. Lck associates with and is activated by the MHC class III-encoded receptor LICAM. Mol Immunol. 2006;43(6):773-781. doi:10.1016/j.molimm.2005.06.028
2. Rudd CE. Upstream-downstream: CD28 cosignaling pathways and T cell function. Immunity. 1996;4(6):527-534. doi:10.1016/s1074-7613(00)80481-2
3. Mustelin T, et al. Differential regulation of Src-family protein tyrosine kinase activities in CD45-deficient T cells. Eur J Immunol. 1995;25(10):2885-2892. doi:10.1002/eji.1830251036
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Alternative Name(s):
IMD22; LSK; p56lck; pp58lck; YT16
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~34 kDa. Calculated MW ~34 kDa.
There are no related publications available for this product.
Receptor Tyrosine Kinases
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