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ROR2, Active

Recombinant human ROR2 (427-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R13-11G


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Catalog No. Pack Size Price (USD)
R13-11G-05 5 ug $226
R13-11G-10 10 ug $325
R13-11G-BULK BULK Contact Us  


Overview:

ROR2 is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. ROR2 is selectively expressed in the chondrocytes of all developing cartilage anlagen, where it is essential during initial growth and patterning, as well as subsequently in the proliferating chondrocytes of mature growth plates, where it is required for normal expansion (1). Thus, ROR2 is selectively expressed in and particularly important for the chondrocyte lineage and loss of ROR2 leads to profound skeletal abnormalities (2).


Gene Aliases:

BDB, BDB1, NTRKR2, MGC163394


Genbank Number:


References:


1. DeChiara, T. M. et al: Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nature Genet. 24: 271-274, 2000.

2. Nomi, M. et al : Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Molec. Cell. Biol. 21: 8329-8335, 2001.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~86 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, Receptor Tyrosine Kinases, WNT Signaling


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