B-Raf(mutant V600E) inhibitor
Catalog No. B08-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| B08-901-05 | 5 mg | $60 | |
| B08-901-25 | 25 mg | $255 | |
| B08-901-BULK | BULK | Contact Us |
Overview:
Selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively)1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors.
References:
1. J Huang et al. J. Hematol. Oncol. 2013 6:1
2. C Ji et al. Drug Des. Dev. Ther. 2016 10:2491
3. R Herr et al. Cancer Res. 2015 75:216
CAS Registry Number:
1195765-45-7
Molecular Formula:
C23H20F3N5O2S2
Appearance:
Off-white powder
Molecular Weight:
519.6
Purity:
>98% (TLC); NMR (conforms)
Solubilization:
May be dissolved in DMSO (30 mg/ml); or ethanol (1 mg/ml, warm)
Aliases:
N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide; GSK2118436
Storage and Stability:
Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
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