Recombinant full-length human PAD1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P312-310G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P312-310G-05 | 5 ug | $226 | |
P312-310G-10 | 10 ug | $325 | |
P312-310G-BULK | BULK | Contact Us |
Overview:
PAD1 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD1 is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by the ubiquitin pathway. The overexpression of PAD1 induced a distinctive pattern of multidrug resistance in mammalian cells and moderate resistance to ultraviolet light (1). PAD1 is also responsible for substrate deubiquitination during proteasomal degradation (2).
Gene Aliases:
HPAD10; PADI1; PDI; PDI1
Genbank Number:
References:
1. Spataro, V. et.al: Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. J. Biol. Chem. 272: 30470-30475, 1997.
2. Yao, T. et.al: A cryptic protease couples deubiquitination and degradation by the proteasome. Nature 419: 403-407, 2002.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
95 kDa
Inflammation
STAY CONNECTED
Fax: 1-604-232-4601