HtrA (also designated as DegP) is a trypsin-like serine protease which contains PDZ domain and involves in heat-shock response, chaperone function, and apoptosis (1). HtrA is an error sensor that specifically represses genetic competence when the overall level of biosynthetic errors in cellular proteins is low (2).
1. Ge X. et.al: DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli. FEBS J. 2013 Dec 26. doi: 10.1111/febs.12701.
2. Cassone M. et.al: The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide. J Biol Chem. 2012 Nov 9;287(46):38449-59.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cell Cycle, Neurobiology, Ser/Thr Kinases