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HTRA2 Protein

Recombinant human HTRA2 (133-358) protein was expressed in E. coli cells using an N-terminal His-tag.
Catalog No. H532-31H


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Catalog No. Pack Size Price (USD)
H532-31H-20 20 ug $215
H532-31H-50 50 ug $435
H532-31H-BULK BULK Contact Us  


Overview:

High temperature requirement protein A2 (HTRA2) is a serine protease that normally resides in mitochondrial membranes and plays a key role in the apoptosis pathways in different pathological conditions including myocardial ischemia/reperfusion injury. Heart ischemia /reperfusion induced HTRA2 translocation from the mitochondria to the cytosol promotes cardiomyocyte apoptosis via a protease activity-dependent and caspase-mediated pathway.


Gene Aliases:

OMI; PARK13; PRSS25


Genbank Number:


References:


1. Suzuki Y, et al: Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11:208–216. 2004

2. Bhuiyan MS, et al: Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury. Cardio-vasc Ther. 26(3):224-32. 2008


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

29 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cell Cycle, Neurobiology, Ser/Thr Kinases


RELATED PRODUCTS


  HTRA1 (161-480) Protein, H531-31H

  HtrA Protein, H531-30CH

  HTRA2 Protein, H532-31H

  HTRA3 Protein, H533-31H


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