Home   >    Proteins   >   Signaling Proteins

PRKAR1A Protein

Recombinant full-length human PRKAR1A Protein was expressed in Sf9 insect cells using a C-terminal His tag.
Catalog No. P57-30H


Shop Online



Catalog No. Pack Size Price (USD)
P57-30H-50 50 ug $435
P57-30H-20 20 ug $215
P57-30H-BULK BULK Contact Us  


Overview:

PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids (1). Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2 (2). A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).


Gene Aliases:

CAR; CNC; CNC1; DKFZp779L0468; MGC17251; PKR1; PPNAD1; PRKAR1; TSE1


Genbank Number:


References:


1. Bossis I, et al: PRKAR1A: normal and abnormal functions. Endocrinology 145: 5452-5458, 2004.

2. Casey M, et al: Mutations in the protein kinase A R1-alpha regulatory subunit cause familial cardiac myxomas and Carney complex. J. Clin. Invest. 106: R31-R38, 2000.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~51 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway


RELATED PRODUCTS


  PKAc beta, Active, P52-10G

  PKA Substrate, C01-58

  PKAc gamma, Active, P53-10G

  Anti-PKAc, P51-63R


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox