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FKBP1A Protein

Recombinant full length human FKBP1A was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. F37-30G


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Catalog No. Pack Size Price (USD)
F37-30G-50 50 ug $435
F37-30G-20 20 ug $215
F37-30G-BULK BULK Contact Us  


Overview:

FKBP1A is a member of the immunophilin protein family which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and Rapamycin. FKBP1A interacts with various type I receptors, including the TGF-beta type I receptor and competitive binding assays show that the type I receptor may be a natural ligand for FKBP1A (1). FKBP1A-deficient mice have normal skeletal muscle but show severe dilated cardiomyopathy and ventricular septal defects that mimick a human congenital heart disorder (2).


Gene Aliases:

FKBP12, FKBP1, PKC12, PKCI2, PPIASE, FKBP-12, FKBP12C


Genbank Number:


References:


1. Wang, T. et.al: Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science 265: 674-676, 1994.

2. Shou, W. et al: Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature 391: 489-492, 1998.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~38.3 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Cardiovascular Disease, Inflammation, Neurobiology, NfkB Pathway



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