PI3K (p55 gamma) also known as PI3K regulatory subunit 3 (PIK3R3) was first identified by 2-hybrid system as a protein that bind to the intracellular domain of IGF1R. PIK3R3 contains 2 Src homology-2 (SH2) domains, an inter-SH2/p110-binding site and a proline-rich motif. PIK3R3 transcript is detected in all fetal and adult tissues except peripheral blood leukocytes. Expression is low in adult liver and most abundant in adult testis. PIK3R3 can bind IGF1R, INSR, and INSR substrate-1 in vitro and the binding requires receptor activation (1).
PIK3R3, p55, p55-GAMMA, FLJ41892, DKFZp686P05226
1. Dey, B R. et al: Cloning of human p55-gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. Gene 209: 175-183, 1998.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling