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PP2Abeta Protein

Recombinant full-length human PP2Abeta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P17-34G


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Catalog No. Pack Size Price (USD)
P17-34G-20 20 ug $215
P17-34G-50 50 ug $435
P17-34G-BULK BULK Contact Us  


Overview:

PP2A is one of the four major Ser/Thr phosphatases which are implicated in the negative control of cell growth and division and encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A (1). PP2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B which is encoded by a diverse set of genes. The interaction was independent of ATP or magnesium ion and the inclusion of PTPA altered the substrate specificity of PP2A, with enhanced phosphotyrosine phosphatase activity and decreased phosphoserine phosphatase activity (2).


Gene Aliases:

PP2A-beta, PP2CB; PPP2CB


Genbank Number:


References:


1. Van Hoof, C. et.al: Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. Genomics 28: 261-272, 1995.

2. Chao, Y. et.al: Structure and mechanism of the phosphotyrosyl phosphatase activator. Molec. Cell 23: 535-546, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~59 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases


RELATED PRODUCTS


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  PP2Cgamma, Active, P07-20G

  PPP2R1A Protein, P162-30G

  PPP2R1B Protein, P162-30BG


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