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FLT1, Active

Recombinant human FLT1 (784-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. F11-11G


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Catalog No. Pack Size Price (USD)
F11-11G-05 5 ug $226
F11-11G-10 10 ug $325
F11-11G-BULK BULK Contact Us  


Overview:

FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS (1). The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers (2). In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing. Both the full length and soluble form of FLT1 show strong binding affinity for VEGF.


Gene Aliases:

FLT, VEGFR1


Genbank Number:


References:


1. Autiero, M. et al: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nature, 2003; 9: 936-943.

2. Fong, G.-H. et al: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature,1995; 376: 65-69.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~94 kDa



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases


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