Home   >    Proteins   >   Protein Kinases

FLT3, Active

Recombinant human FLT3 (571-993) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. F12-11G


Shop Online



Catalog No. Pack Size Price (USD)
F12-11G-05 5 ug $226
F12-11G-10 10 ug $325
F12-11G-BULK BULK Contact Us  


Overview:

FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors (1). FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3 (2). The consequence of either FLT3-ITD or activating loop mutations is the constitutive activation of the tyrosine kinase activity.


Gene Aliases:

FLK2, STK1, CD135


Genbank Number:


References:


1. Christensen, J L. et al : Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Nat. Acad. Sci. 98: 14541-14546, 2001.

2. Gilliland, D G. et al: Role of FLT3 in leukemia. Curr Opin Hematol. 2002 Jul;9(4):274-81.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases


RELATED PRODUCTS


  PDGFR alpha, Active, P12-11G

  Kinase Assay Buffer I, K01-09

  FGFR3, Active, F06-11G

  PDGFR alpha, Active, P12-18G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox