Recombinant human KAT3B (EP300) (532-1153; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K312-31BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
K312-31BG-20 | 20 ug | $215 | |
K312-31BG-50 | 50 ug | $435 | |
K312-31BG-BULK | BULK | Contact Us |
Overview:
KAT3B (also known as EP300) encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein that functions as a histone acetyltransferase. KAT3B regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. KAT3B binding is a highly accurate process and can be used for identifying enhancers and their associated activities (1). KAT3B is also useful in the study of the role of tissue-specific enhancers in human biology and diseases on a genome wide scale. Defects in KAT3B gene are a cause of Rubinstein-Taybi syndrome that play a important role in epithelial cancer and act as a classic tumor suppressor gene (2).
Gene Aliases:
KAT3B; EP300; p300
Genbank Number:
References:
1. Visel, A. et.al: ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457: 854-858, 2009.
2. Gayther, S. A. et.al: Mutations truncating the EP300 acetylase in human cancers. Nature Genet. 24: 300-303, 2000.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~120 kDa
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway
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