Recombinant human TAOK2 (1-314) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T25-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T25-11G-05 | 5 ug | $226 | |
T25-11G-10 | 10 ug | $325 | |
T25-11G-BULK | BULK | Contact Us |
Overview:
Thousand and one-amino acid protein kinase 2 (TAOK 2) is part of the stress-sensitive kinase cascade and activation of and binding to MKK3 by TAOK2 implicates it in the regulation of the p38-containing stress-responsive MAP kinase pathway (1). TAOK2 protein kinase activates p38 mitogen-activated protein kinase cascade in vitro and in cells by phosphorylating the MAP/ERK kinases MKK3 and MKK6. TAO2 may play an important role in the activation of specific intracellular signaling pathways that are unique to osmotic stress (2).
Gene Aliases:
PSK, PSK1, TAO1, TAO2, MAP3K17, KIAA0881
Genbank Number:
References:
1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273:28625-32.
2. Chen, Z. et al: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J. Biol. Chem. 2003;278:22278-83.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~63 kDa
Garg R et al., Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning Journal of cell science February 2020 10.1242/jcs.235895
Morris J et al et al., Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease Journal of Biological Chemistry April 2013 10.1074/jbc.M112.448183
Morris J et al et al., A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies Acta Neuropathologica Communications May 2018 10.1186/s40478-018-0539-8
Yeng Koo Chuay et al., Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells Mol Cancer Thera August 2017 10.1158/1535-7163.MCT-17-0077
et al., Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Cancer cell February 2020
Cancer, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases
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