Overview:

The ubiquitin-specific protease 46 (USP46) belongs to the ubiquitin-specific protease family, a subfamily of deubiquitinating enzymes (DUBs) (1). USP46 requires the interaction with WDR48 to have a higher activity than by its own (2). The expression of USP46 is associated with PHLPP in colorectal patient cancer specimens and USP46 serves as a stabilizer of PHLPP via the suppression of Akt signaling pathway in colon cancer cells (3).

Gene Aliases:

Ubiquitin specific peptidase 46

Genbank Number:

NM_022832

References:

1. Quesada V, et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):54-62.

2. Yin J, et al. Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure. 2015 Nov 3; 23(11):2043-54.

3. Li X, et al. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene. 2013 Jan 24; 32(4):471-8.