Recombinant full-length human IKK gamma was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I25-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
I25-30G-20 | 20 ug | $215 | |
I25-30G-50 | 50 ug | $435 | |
I25-30G-BULK | BULK | Contact Us |
Overview:
IKKgamma is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKKgamma forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha (1). IKKgamma associates with activated ATM after the induction of DNA double-strand breaks (2). ATM phosphorylates serine-85 of IKKgamma to promote its ubiquitin-dependent nuclear export.
Gene Aliases:
IKBKG; AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IP; IP1; IP2; IPD2; NEMO
Genbank Number:
References:
1. Rothwarf, D. M. et al: IKK-gamma is an essential regulatory subunit of the I-kappa-B kinase complex. Nature 395: 297-300, 1998.
2. Wu, Z-H. et al: Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311: 1141-1146, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~73 kDa
There are no related publications available for this product.
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