Recombinant full-length human SETMAR was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S347-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S347-30G-20 | 20 ug | $215 | |
S347-30G-50 | 50 ug | $435 | |
S347-30G-BULK | BULK | Contact Us |
Overview:
SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends (1). SETMAR has histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair (2). Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element.
Gene Aliases:
METNASE
Genbank Number:
References:
1. Lee, S.-H.et.al: The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc. Nat. Acad. Sci. 102: 18075-18080, 2005.
2. Liu, D.et.al: The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase. Molec. Cell. Biol. 27: 1125-1132, 2007.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66-69 kDa
There are no related publications available for this product.
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