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Stathmin Protein

Recombinant full-length human Stathmin protein was expressed in E. coli cells using an N-terminal His tag.
Catalog No. S71-30H




Catalog No. Pack Size Price (USD)
S71-30H-20 20 ug $215
S71-30H-50 50 ug $435
S71-30H-BULK BULK Contact Us  


Overview:

Stathmin is a ubiquitous, highly conserved protein present in the cytoplasm in a variety of unphosphorylated and phosphorylated forms. Stathmin functions as an intracellular relay integrating regulatory signals of the cellular environment (1). Stathmin is involved in the regulation of the microtubule filament system. Stathmin binds tubulin in a ternary complex, with 2 tubulins for every stathmin and this complex interferes with microtubule dynamics in vitro and in vivo. Overexpression of several stathmin mutants suggest that stathmin induces depolymerization of interphase and mitotic microtubules in its unphosphorylated state, but is inactivated by phosphorylation in mitosis (2).


Gene Aliases:

STMN1; C1orf215; FLJ32206; Lag; LAP18; MGC138869; MGC138870; OP18; PP17; PP19; PR22; SMN


Genbank Number:


References:


1. Sobel, A. Stathmin: a relay phosphoprotein for multiple signal transduction? Trends Biochem. Sci. 16: 301-305, 1991.

2. Gavet, O. et al: The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111: 3333-3346, 1998.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~19 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Invasion/Metastasis, Neurobiology



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