Overview:

PTPRB contains multiple repeated fibronectin type-lll domains extracellularly, a single transmembrane segment and only one protein tyrosine phosphatase (PTP) domain intracellularly, and thus belongs to receptor type PTP family (1). PTPRB negatively regulates angiogenesis and blood vessel remodeling via interacting with vascular growth factor tyrosine kinases such as TIE2, CDH5, and KDR (2). PTPRB has been reported to be one of the recurrent mutations in angiosarcoma tumors (3).

Gene Aliases:

PTPB, HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA

Genbank Number:

NM_002837

References:

1. Crossland S. et al: Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase. Biochem J. 1996 Oct 1;319 ( Pt 1):249-54.

2. Mantilidewi KI. et al: Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation. J Biol Chem. 2014 Mar 7;289(10):6451-61.

3. Behjati S, et al: Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet. 2014 Apr;46(4):376-379.