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TRKB, Active

Recombinant human TRKB (455-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N17-11G


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Catalog No. Pack Size Price (USD)
N17-11G-05 5 ug $226
N17-11G-10 10 ug $325
N17-11G-BULK BULK Contact Us  


Overview:

TRKB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TRKB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and mood disorders.


Gene Aliases:

NTRK2, GP145-TrkB


Genbank Number:


References:


1. Gregory, T. et al: Signal Transduction Mediated by the Truncated trkB Receptor Isoforms, trkB.T1 and trkB.T2. J. Neurosci. 1997; 17( 8); 2683-2690.

2. Pearse, R N. et al: A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 2005;105(11):4429-36.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~67 kDa



There are no related publications available for this product.


RESEARCH AREAS

Neurobiology, Receptor Tyrosine Kinases


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