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BLK, Active

Recombinant full-length human BLK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. B02-10G


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Catalog No. Pack Size Price (USD)
B02-10G-05 5 ug $226
B02-10G-10 10 ug $325
B02-10G-BULK BULK Contact Us  


Overview:

BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. BLK is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells (1). Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of BLK (2).


Gene Aliases:

MGC10442


Genbank Number:


References:


1. Dymecki, SM. et al: Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6.

2. Burkhardt, AL. et al: Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7410-4.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~84 kDa



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, Inflammation


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