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PDE7B, Active

Full-length recombinant human PDE7B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P95-30BG


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Catalog No. Pack Size Price (USD)
P95-30BG-05 5 ug $259
P95-30BG-10 10 ug $380
P95-30BG-BULK BULK Contact Us  


Overview:

PDE7B is a cAMP-specific phosphodiesterase and a member of the cyclic nucleotide phosphodiesterase family that catalyzes the hydrolysis of cAMP to the corresponding 5'-monophosphate and provides a mechanism to downregulate cAMP signaling (1). PDE7B is over-expressed in chronic lymphocytic leukemia and inhibition of PDE7B leads to induction of apoptosis (2). PDE7B has been identified as a candidate gene for measuring treatment response to risperidone and may confer susceptibility to schizophrenia.


Gene Aliases:

MGC88256; bA472E5.1


Genbank Number:


References:


1. Hetman, J. M. et.al: Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc. Nat. Acad. Sci. 97: 472-476, 2000.

2. Ikeda, M. et al: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry. 2010 Feb 1;67(3):263-9.


Specific Activity:

Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, Inflammation, Phosphodiesterases


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