Overview:

Elongin-B (ELOB) is a pivotal component of the Elongin complex involved in transcription elongation and a crucial subunit of the E3 ubiquitin-protein ligase complex. In the Elongin complex, ELOB acts as a stabilizing bridge between Elongin-A and Elongin-C, stabilizing the complex and enabling its functionality in transcription elongation in order to maintain proper gene expression. Furthermore, ELOB, as part of the E3 ligase complex, participates in protein degradation through the ubiquitin-proteasome pathway, influencing cellular homeostasis by regulating protein turnover.

Genbank Number:

NM_007108.3

References:

1. Aso T, et al. (1995). A molecular structure in the replication complex of foot-and-mouth disease virus for RNA synthesis. J Biol Chem, 270(23), 13576-13583.
2. Ivan M, et al. (2001). HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science, 292(5516), 464-468.