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p70S6Kb, Unactive

Recombinant full-length human p70S6Kb was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R22-14G

Catalog No. Pack Size Price (USD)
R22-14G-20 20 ug $215
R22-14G-50 50 ug $435
R22-14G-BULK BULK Contact Us  


p70S6Kb is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and is activated by mitogenic stimuli, including growth factors, cytokines, and phorbol esters. p70S6Kb contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. PI3 kinase pathway and mTOR are involved in the activation of p70S6Kb but other pathways can also activate this target protein.

Gene Aliases:

RPS6KB2, STK14B, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K2, p70(S6K)-beta, S6K-beta2, SRK

Genbank Number:


1. Gout, I. et al: Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. J. Biol. Chem. 273: 30061-30064, 1998.

2. Saitoh, M. et al: Cloning and characterization of p70(S6K-beta) defines a novel family of p70 S6 kinases. Biochem. Biophys. Res. Commun. 253: 470-476, 1998.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~85 kDa

Product Datasheets


AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases


  PDK1, Active, P14-10H

  AMPK (A2/B1/G1), Active, P48-10H

  AMPK (A1/B1/G3), Active, P56-10H

  p70S6K, Unactive, R21-14H



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