Recombinant full-length human BID was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. B59-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
B59-30G-20 | 20 ug | $215 | |
B59-30G-50 | 50 ug | $435 | |
B59-30G-BULK | BULK | Contact Us |
Overview:
BID is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2 (1). BID is a member of the BCL-2 family of cell death regulators and is a mediator of mitochondrial damage induced by caspase-8 (CASP8). BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Multiple alternatively spliced transcript variants of BID have been found, but the full-length nature of some variants has not been defined. BID together with Cathepsins play an important role in the actions of Camptothecin on breast cancer cells (2).
Gene Aliases:
FP497, MGC42355, MGC15319
Genbank Number:
References:
1. Hayakawa, A. et al:, Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis. Apoptosis. 2008;13(4):523-30.
2. Lamparska-Przybysz. M. et al: Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin. J Physiol Pharmacol. 2005 Jun;56 Suppl 3:159-79.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~52kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Neurobiology
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