Recombinant human HRAS (2-186) was expressed in E.coli cells using an N-terminal His tag.
Catalog No. R105-310H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R105-310H-05 | 5 ug | $160 | |
R105-310H-10 | 10 ug | $226 | |
R105-310H-BULK | BULK | Contact Us |
Overview:
The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer.
Gene Aliases:
C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; HRAS; H-RASIDX; HAMSV; K-RAS; N-RAS; RASH1
Genbank Number:
References:
1. Shih, T. Y., et al: Structure and function of p21 ras proteins.
Gene Amplif Anal. 1986;4:53-72.
2. Rodriguez-Viciana, P.: Cancer targets in the Ras pathway.
Cold Spring Harb Symp Quant Biol. 2005;70:461-7.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~23 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases
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