Home   >    Proteins   >   Protein Kinases

NEK6, Active

Recombinant full-length human NEK6 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N08-10G


Shop Online



Catalog No. Pack Size Price (USD)
N08-10G-05 5 ug $226
N08-10G-10 10 ug $325
N08-10G-BULK BULK Contact Us  


Overview:

NEK6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA family (1). Nek6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. Nek6 is phosphorylated and activated during M phase of the cell cycle (2). Inhibition of Nek6 function by either overexpression of an inactive Nek6 mutant or elimination of endogenous Nek6 by siRNA arrests cells in M phase and triggers apoptosis.


Gene Aliases:

SID6-1512


Genbank Number:


References:


1. Kandli,M. et al: Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96.

2. Yin, MJ. Et al: The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem. 2003 Dec 26;278(52):52454-60.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~63 kDa



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  NEK2, Active, N03-10G

  NEK7, Active, N09-10G

  Kinase Assay Buffer I, K01-09

  NEK11, Active, N13-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox