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SGK3, Active

Recombinant full-length human SGK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S08-10G


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Catalog No. Pack Size Price (USD)
S08-10G-05 5 ug $226
S08-10G-10 10 ug $325
S08-10G-BULK BULK Contact Us  


Overview:

SGK3 is a member of the SGK family and encodes a phosphoprotein with a PX (phox homology) domain. PKD1 can phosphorylate and activate SGK3 in vitro (1). A 10-fold increase in PKD1 increases the phosphorylation status of SGK3. When expressed in human embryonic kidney cells, IGF1 and peroxide significantly activate SGK3, and the activation could be reduced by preincubation with inhibitors of PI3 kinase. A yeast 2-hybrid screen found direct interaction between human SGK3 and GSK3β. SGK3 phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels (2).


Gene Aliases:

CISK, SGKL


Genbank Number:


References:


1. Kobayashi, T. et al: Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem. J. 344: 189-197, 1999.

2. Gamper, N. et al: K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Europ. J. Physiol. 445: 60-66, 2002.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~82 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


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  SGKtide, S08-58


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