Overview:

The PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) gene encodes the regulatory subunit p85α of phosphoinositide 3-kinase (PI3K), a critical signaling enzyme involved in various cellular processes, including cell growth, survival, proliferation, and migration. The p85α regulatory subunit contains multiple domains, including the Src homology 3 (SH3) domain. The SH3 domain is a protein module of approximately 50-70 amino acids that is involved in protein-protein interactions, particularly with proline-rich motifs in target proteins. SH3 domains are crucial for mediating signaling pathways, cellular adhesion, and intracellular trafficking by promoting the assembly of signaling complexes. The SH3 domain within PIK3R1 is likely important for protein-protein interactions, enabling the association of PI3K with other signaling molecules and facilitating the transduction of cellular signaling cascades.

Genbank Number:

NM_181523.3

References:

1. Yu J, Zhang Y, McIlroy J, Rordorf-Nikolic T, Orr GA, Backer JM. Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol. 1998;18(3):1379-1387. doi:10.1128/MCB.18.3.1379
2. Fruman DA, Meyers RE, Cantley LC. Phosphoinositide kinases. Annu Rev Biochem. 1998;67:481-507. doi:10.1146/annurev.biochem.67.1.481
3. Huang CH, Mandelker D, Schmidt-Kittler O, et al. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science. 2007;318(5857):1744-1748. doi:10.1126/science.1150799