Home   >    Proteins   >   Protein Kinases

c-MER, Active

Recombinant human c-MER (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M51-11G

Shop Online

Catalog No. Pack Size Price (USD)
M51-11G-05 5 ug $226
M51-11G-10 10 ug $325
M51-11G-BULK BULK Contact Us  


c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family (1). The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product (2).

Gene Aliases:


Genbank Number:


1. Graham, D. K. et al: Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5: 647-657, 1994.

2. Gal, A. et al: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nature Genet. 26: 270-271, 2000.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~58 kDa

Product Datasheets


Cardiovascular Disease, Inflammation, Receptor Tyrosine Kinases


  Kinase Dilution Buffer IV, K24-09

  Kinase Assay Buffer II, K02-09

  ATP Stock Solution, A50-09

  ROR2, Active, R13-11G



Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox