Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Erlotinib HCl

EGFR kinase inhibitor
Catalog No. E10-900C

For enquiry on all Kinase Inhibitors email us at orders@signalchem.com

Catalog No.	Pack Size	Price (USD)
E10-900C-10	10 mg	$55
E10-900C-100	100 mg	$120
E10-900C-BULK	BULK	Contact Us

Overview:

Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM) (1). Potent inhibitor of mutant JAK2-V617F (2). Weaker inhibitor of ErbB-2 kinase (Ki = 1 uM) ErbB-4 kinase (Ki = 1.5 uM) (3).

References:

1. JD Moyer et al. Cancer Res. 1997 57:4838

2. Z Li et al. J. Biol. Chem. 2007 282:3428

3. ER Wood et al. Cancer Res. 2004 64:6652

CAS Registry Number:

183319-69-9

Molecular Formula:

C₂₂H₂₃N₃O₄ ∙ HCl

Appearance:

White to off-white powder

Melting Point:

N/A

Molecular Weight:

429.9

Purity:

>98% (TLC); NMR (Conforms)

Solubilization:

May be dissolved in DMSO (18 mg/ml, warm)

Aliases:

N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, hydrochloride

Storage and Stability:

Storage, Stability and Shipping

Molecular Structure:

Product Datasheets

T2257-53

There are no related publications available for this product.

RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases