Overview:

The Dedicator of Cytokinesis 5 (DOCK5) protein belongs to the DOCK family of guanine nucleotide exchange factors (GEFs) that play a crucial role in the regulation of Rho GTPases, particularly RhoA, Rac1, and Cdc42, which are pivotal in cellular signaling and cytoskeletal dynamics. The SH3 (Src homology 3) domain is a conserved protein module within DOCK5 that is implicated in protein-protein interactions and signaling pathways. The SH3 domain is a structurally conserved protein module, typically composed of about 50-70 amino acids, and is known to mediate protein-protein interactions through recognition of specific proline-rich motifs in binding partners. This domain plays a significant role in signaling pathways, cellular adhesion, and intracellular trafficking by facilitating the assembly of signaling complexes.

Genbank Number:

NM_024940.8

References:

1. Côté J-F, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 2007;17(8):383-393. doi:10.1016/j.tcb.2007.06.006
2. Meller N, Merlot S, Guda C. CZH proteins: a new family of Rho-GEFs. J Cell Sci. 2005;118(Pt 21):4937-4946. doi:10.1242/jcs.02642
3. Zhu J, et al. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS One. 2010;5(6):e11128. doi:10.1371/journal.pone.0011128