p38 MAP kinase inhibitor
Catalog No. M39-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M39-900-05 | 5 mg | $105 | |
| M39-900-25 | 25 mg | $400 | |
| M39-900-BULK | BULK | Contact Us |
Overview:
Potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site (1). (IC50=18 nM). Displays anti-inflammatory activity (2) but differential effects on inflammatory genes (3). Cell permeable.
References:
1. C Pargellis et al. Nat. Struct. Biol. 2002 9:268
2. J Branger et al. J. Immunol. 2002 168:4070
3. H Joos et al. Br. J. Pharmacol. 2010 160:1252
CAS Registry Number:
285983-48-4
Molecular Formula:
C31H37N5O3
Appearance:
White to off-white crystalline solid
Melting Point:
136-140oC
Molecular Weight:
527.7
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved DMSO (50 mg/ml); or ethanol (30 mg/ml)
Aliases:
1. 1-[5-tert-butyl-2-(4-methylphenyl) pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy) naphthalen-1-yl] urea
2. BIRB-796
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
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