Recombinant full-length human MYCN was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M86-34G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M86-34G-20 | 20 ug | $215 | |
| M86-34G-50 | 50 ug | $435 | |
| M86-34G-BULK | BULK | Contact Us |
Overview:
MYCN is a basic helix-loop-helix transcription factor first identified in neuroblastoma and is a member of the MYC proto-oncogene family along with MYCC and MYCL. MYC proteins affect transcription of many genes thus regulating proliferation, metabolism, apoptosis, differentiation and immune surveillance. Ubiquitin-dependent proteasome degradation of MYCN in neural stem/progenitor cells is required for the arrest of proliferation and the start of differentiation. Enhanced USP7 expression is seen in neuroblastoma patients with poorer prognosis due to deubiquination of MYCN by USP7, thereby preventing degradation of MYCN (1). Overexpression of MYCN is closely related with high-cancers, early distant metastasis, and poor clinical prognosis (2).
Genbank Number:
References:
1. Liu, R. et al: Molecular Mechanisms of MYCN Dysregulation in Cancers. Front Oncol. 2020, 10:625332.
2. Yang, Y. et al: MYCN protein stability is a better prognostic indicator in neuroblastoma. BMC Pediatr. 2022, 22:404.
Alternative Name(s):
bHLHe37; MODED; MYCNsORF; MYCNsPEP; N-myc; NMYC; ODED
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Molecular Weight:
Observed MW ~95 kDa. Calculated MW ~80 kDa.
There are no related publications available for this product.
Cancer, Cell Cycle
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