ARPP19 Protein
Full-length recombinant human ARPP19 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. A76-54G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A76-54G-50 | 50 ug | $105 | |
| A76-54G-BULK | BULK | Contact Us |
Full-length recombinant human ARPP19 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. A76-54G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A76-54G-50 | 50 ug | $105 | |
| A76-54G-BULK | BULK | Contact Us |
Overview:
ARPP19, cAMP-regulated phosphoprotein 19, is specifically phosphorylated at Ser-62 during mitosis by MASTL, also known as the Greatwall kinase. The phos-phorylation of ARPP19 leads to inactivation of PP2A through its interaction with PR55-delta, which is essential in maintaining the activity of CDK1/cyclin B1 and promoting mitotic G2/M transition (1). Significant reduction of ARPP-19 was observed in brains of Alzheimer’s disease and Down syndrome (2). ARPP-19 was also found to contribute to tumor growth in hepatocellular carcinoma and papillary carcinoma (3).
Gene Aliases:
ARPP-16; ARPP-19; ARPP16; ENSAL
Genbank Number:
References:
1. Gharbi-Ayachi, A., et al. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science. 330(6011): 1673-1677, 2010.
2. Kim, S. H., et al. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 61: 263-272, 2001.
3. Song, H., et al. Increased ARPP-19 expression is associated with hepatocellular carcinoma. Int J Mol Sci. 16(1): 178-192, 2014.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
|
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
46 kDa
Cell Cycle, Cellular Stress
STAY CONNECTED
Fax: 1-604-232-4601
et al., The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets Cells February 2020 
Toll Free: 1-866-954-6273
info@signalchem.com