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MEK7, Active

Recombinant full-length human MEK7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M08-10G


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Catalog No. Pack Size Price (USD)
M08-10G-05 5 ug $259
M08-10G-10 10 ug $380
M08-10G-BULK BULK Contact Us  


Overview:

Mitogen-activated protein kinase 7 (MKK7 or MEK7) is a dual-specificity protein kinase of the STE7 family. Directly phosphorylates the Thr-Pro-Tyr motif located in the activation loop of JNK1/2 and activate the kinases in response to environmental stress, pro-inflammatory cytokines or developmental cues. The activation of MKK7 is mediated by various MAPKKKs, including mixed lineage protein kinases (MLKs) and MAPK/ERK kinase (MEK) kinase (MEKK1).


Gene Aliases:

MAP2K7; MKK7; JNKK2; MAPKK7; PRKMK7; SKK4


Genbank Number:


References:


1. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 103(2):239-52, 2000.

2. Chang L, et al: Mammalian MAP kinase signalling cascades. Nature. 410(6824):37-40, 2001.

3. Asaoka Y, et al: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J Biochem. 48(4):393-401, 2010.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~78 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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