Recombinant human TIE 2 (771-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T04-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T04-11G-05 | 5 ug | $226 | |
T04-11G-10 | 10 ug | $325 | |
T04-11G-BULK | BULK | Contact Us |
Overview:
TIE 2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE 2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE 2 receptor tyrosine kinase (1). SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE 2 function. TIE 2 expression is upregulated in the endothelium of vascular "hot spots" in human breast cancer specimens. However, TIE 2 is also overexpressed in areas of active angiogenesis in normal tissues (2).
Gene Aliases:
TEK, VMCM, VMCM1, CD202B
Genbank Number:
References:
1. Woolf, A S. et al: Angiopoietin growth factors and Tie receptor tyrosine kinases in renal vascular development. Pediatr Nephrol. 2001 Feb;16(2):177-84.
2. Peters, K G. et al: Functional significance of Tie2 signaling in the adult vasculature. Recent Prog Horm Res. 2004;59:51-71.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~61 kDa
B. Hossain Mohammad et al., TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1 Science Advances April 2016 10.1126/sciadv.1501290
et al., Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Cancer cell February 2020
Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Receptor Tyrosine Kinases
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