Recombinant full-length human HO1 was expressed in E. coli cells using an N-terminal GST tag
Catalog No. H20-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
H20-30G-20 | 20 ug | $215 | |
H20-30G-50 | 50 ug | $435 | |
H20-30G-BULK | BULK | Contact Us |
Overview:
HO1 (Heme oxygenase 1) catalyzes the oxidative cleavage of heme to biliverdin and is one of the main genes controlling heme synthesis and catabolism. HO1 plays a protective role in various disorders and can ameliorate experimental MN via multiple pathways, including anti-oxidative and immunomodulatory effects (1). Exposure of primary hepatocytes to carbon monoxide and nitric oxide results in dramatic induction of HO1 in dose- and time-dependent manner and this induction is blocked by MAP kinase inhibitors (MAPKs) but not by inhibitors of PI3 kinase pathway (2).
Gene Aliases:
HMOX1, HSP32, bK286B10
Genbank Number:
References:
1. Chia-Chao, W.u. et al: HO-1 induction ameliorates experimental murine membranous nephropathy: anti-oxidative, anti-apoptotic and immunomodulatory effects. Nephrology Dialysis Transplantation, 2008; 23(10):3082-3090.
2. Lee, B S. et al: . Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells. Biochem Biophys Res Commun. 2006 May 12;343(3):965-72.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~56 kDa
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology
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