Recombinant full-length human IRAK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I11-34G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
I11-34G-20 | 20 ug | $215 | |
I11-34G-50 | 50 ug | $435 | |
I11-34G-BULK | BULK | Contact Us |
Overview:
IRAK3 or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which is essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling (1). IRAKM mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis (2). Mutations in IRAK3 are associated with a susceptibility to asthma.
Gene Aliases:
IRAK-M
Genbank Number:
References:
1. Del Fresno, C. et.al: Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. J. Immun. 174: 3032-3040, 2005.
2. Deng, J. C. et.al: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~96 kDa
There are no related publications available for this product.
Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
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