CAS Registry Number:

93076-89-2

Molecular Formula:

C₂₇H₂₆FN₃OS

Appearance:

White Powder

Melting point:

N/A

Molecular weight:

459.6

Purity:

>98% (HPLC); NMR (conforms)

solubility:

May be dissolved DMSO (25 mg/ml)

Storage and Stability:

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

Scientific background:

R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotopes (IC50=2.8 µM in intact platelets) (1). Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism (2). Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes (3). Blocks filovirus internalization in host cells (4).

Molecular structure:

Aliases:

6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one