GSK3 inhibitor
Catalog No. G08-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| G08-900-05 | 5 mg | $95 | |
| G08-900-25 | 25 mg | $390 | |
| G08-900-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM (1). The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells (2) . Promotes proliferation in mammalian cardiomyocytes (2). A potent inhibitor of malignant lymphoid cell proliferation (3).
References:
1. L Meijer et al. Chem. Biol. 2003 10:1255
2. AS Tseng et al. Chem. Biol. 2006 13:957
3. A Chebel et al. Leuk. Lymphoma 2009 50:2049
CAS Registry Number:
667463-62-9
Molecular Formula:
C16H10BrN3O2
Appearance:
Purple powder
Melting Point:
263-265oC
Molecular Weight:
356.2
Purity:
98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)
Solubilization:
Soluble in DMSO (15 mg/ml); or Ethanol (4 mg/ml, warm)
Aliases:
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
Storage and Stability:
Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months.
Molecular Structure:
|
There are no related publications available for this product.
AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com