PI3K inhibitor
Catalog No. P27-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P27-900-01 | 1 mg | $90 | |
| P27-900-05 | 5 mg | $195 | |
| P27-900-BULK | BULK | Contact Us |
Overview:
Inhibits PI3-kinase with selectivity for p110alpha (IC50=0.1 nM). Displays antitumor activity. Irreversible. Cell permeable.
References:
1. NT Ihle et al. Mol. Cancer Ther. 2004 3:763
CAS Registry Number:
502632-66-8
Molecular Formula:
C29H35NO8
Appearance:
Orange powder
Melting Point:
N/A
Molecular Weight:
525.6
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (25 mg/ml)
Aliases:
(1E,4S,4aR,5R,6aS,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino) methylene]-4,4a,5,6,6a,8,9,9-a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta [5,6] naphtha [1,2-c] pyran-2,7,10(1H)-trione
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
|
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
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Fax: 1-604-232-4601
Yalcin Abdullah et al., Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases* Journal of Biological Chemistry November 2012 10.1074/jbc.M109.016816 
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