Kinase inhibitor (pan)
Catalog No. K10-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K10-900-1000 | 1 mg | $75 | |
| K10-900-5000 | 5 mg | $150 | |
| K10-900-BULK | BULK | Contact Us |
Overview:
Potent pan-specific protein kinase inhibitor including PKC (IC50= 0.7 nM), PKA (IC50= 7 nM), PKG (IC50= 8.5 nM) and many others. Induces apoptosis in a large variety of cell types. Cell permeable.
References:
1. T Tamaoki et al. Biochem. Biophys. Res. Commun. 1986 135:397
2. H Matsumoto et al. Biochem. Biophys. Res. Commun. 1989 158:105
3. G Preta et al. FEBS Lett. 2012 586:747
4. M Akbar et al. J. Neurochem. 2002 82:655
CAS Registry Number:
62996-74-1
Molecular Formula:
C28H26N4O3
Appearance:
White to yellow powder or lyophilized solid
Melting Point:
N/A
Molecular Weight:
466.50
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in: DMSO (50 mg/ml); or ethanol (2 mg/ml, warm)
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
|
Alias:
AM-2282; STS
Artamonov MV et al., RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger Science Signaling October 2018 10.1126/scisignal.aar3924
S. Huang Bing et al., Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology July 2012 10.1152/ajpregu.00381.2011
Frost Danielle et al., β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites PLoS One May 2011 10.1371/journal.pone.0019264
et al., Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. Nature cell biology June 2018
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling
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