Catalog No. B10-901
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Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM (1) and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM (2).
1. S Mahajan et al. J. Biol. Chem. 1999 274:9587
2. A Vassilev et al. J. Biol. Chem. 1999 274:1646
CAS Registry Number:
98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)
DMSO (10 mg/ml) and ethanol (15 mg/ml)
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
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Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway