JAK2 inhibitor
Catalog No. J02-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| J02-901-05 | 5 mg | $45 | |
| J02-901-25 | 25 mg | $180 | |
| J02-901-BULK | BULK | Contact Us |
Overview:
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src.
References:
1. LH Wang et al. J. Immunol. 1999 162:3897
2. N Meydan et al. Nature 1996 379:645
CAS Registry Number:
133550-30-8
Molecular Formula:
C17H14N2O3
Appearance:
Tan powder
Melting Point:
N/A
Molecular Weight:
294.3
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (30 mg/ml) or ethanol (10 mg/ml)
Aliases:
(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.
Molecular Structure:
|
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com