Tyrosine kinase inhibitor
Catalog No. K11-900B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K11-900B-05 | 5 mg | $60 | |
| K11-900B-25 | 25 mg | $180 | |
| K11-900B-BULK | BULK | Contact Us |
Overview:
An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation (1). Inhibits the growth of a number of cancer cell lines (2). An extremely useful tool for exploring EGF-mediated cellular signaling (3).
References:
1. DW Fry et al. Science 1994 265:1093
2. M Bos et al. Clin. Cancer Res. 1997 3:2099
3. MP Tetreault et al. J. Cell. Biochem. 2008 105:1240
CAS Registry Number:
153436-54-5
Molecular Formula:
C16H14BrN3O2 ∙ HCl
Appearance:
White to off-white solid
Melting Point:
N/A
Molecular Weight:
396.7
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (5 mg/ml, warm)
Aliases:
1. 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
2. PD-153,035
3. SU-5271
4. ZM-252868
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Metabolic Disorder, Ser/Thr Kinases
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