Kinase inhibitor
Catalog No. K10-900D
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K10-900D-1000 | 1000 ug | $75 | |
| K10-900D-5000 | 5 mg | $240 | |
| K10-900D-BULK | BULK | Contact Us |
Overview:
Potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM) (1). Inhibits CaMK (Ki = 1.8 nM) (2) and phosphorylase kinase (IC50 = 1.7 nM) (3) as well as other kinases (4). Induces apoptosis (5). Cell permeable.
References:
1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436
2. Y Hashimoto et al. Biochem. Biophys. Res. Commun. 1991 181:423
3. MM Berg et al. J. Biol. Chem. 1992 267:13
4. UT Ruegg et al. Trends Pharmacol. Sci. 1989 10:218
5. T Mohri et al. Cancer Invest. 1999 17:391
CAS Registry Number:
99533-80-9
Molecular Formula:
C27H21N3O5
Appearance:
White to off-white powder
Melting Point:
N/A
Molecular Weight:
467.5
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (100 mg/ml)
Aliases:
2,3,9S,10R,11,12R-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
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There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling
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