Overview:

Several WD40-repeat (WDR) proteins interact with and regulate the activity of USPs. A subfamily of USPs constituting of USP1, USP12, and USP46 share a common WDR partner WDR48/ UAF1 that stimulates the activity of these USPs (1). USP1/WDR48 complex controls the cellular levels of monoubiquitinated FANCD2 DNA repair, a regulation pivotal for an intact Fanconi anemia pathway (2). WDR48 in complex with USP12 suppresses proliferation of tumor by enhancing stability of PHLPP1 (3).

Genbank Number:

NM_020839

References:

1. Hanwen, Z. et al: Structural insights into the activation of USP46 by WDR48 and WDR20. Cell Discov. 5:34, 2019.
2. Cohn, M.A. et al: UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem. 284(8):5343-5351, 2009.
3. Gangula, N.R. et al: WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). J Biol Chem. 288(48):34545-54, 2013.