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DRAK2 (STK17B), Active

Recombinant full-length human DRAK2 (STK17B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S34-10G


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Catalog No. Pack Size Price (USD)
S34-10G-05 5 ug $226
S34-10G-10 10 ug $325
S34-10G-BULK BULK Contact Us  


Overview:

DRAK2 is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis (1). DRAK2 is selectively important for T-cell survival and inhibition of DRAK2 has therapeutic potential for autoimmune disease (2). T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of DRAK2 can affect autoimmune disease susceptibility without generalized suppression of the immune system (3).


Gene Aliases:

DRAK2; STK17B


Genbank Number:


References:


1. Sanjo, H. et.al: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J. Biol. Chem. 273: 29066-29071, 1998.

2. Ramos, S. J. et.al: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J. Immun. 181: 7606-7616, 2008.

3. McGargill, M. A. et.al: Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J. Immun. 181: 7593-7605, 2008.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~69 kDa



RESEARCH AREAS

Apoptosis/Autophagy, Metabolic Disorder, Ser/Thr Kinases


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